Many machine learning algorithms can cope well with prediction and classification， but these methods suffer from poor prediction accuracy and F1 score when they are used on medical datasets with small samples and large feature spaces. To improve the accuracy and F1 score of liver transplantation complication prediction， a prediction and classification method of liver transplantation complications based on Transfer Component Analysis （TCA） and Support Vector Machine （SVM） was proposed. In this method， TCA was used for mapping and dimension reduction of the feature space， and the source domain and the target domain were mapped to the same reproducing kernel Hilbert space， thereby achieving the adaptivity of edge distribution. The SVM was trained in the source domain after transferring， and the complications were predicted in the target domain after training. In the liver transplantation complication prediction experiments for complication Ⅰ， complication Ⅱ， complication Ⅲa， complication Ⅲb， and complication Ⅳ， compared with the traditional machine learning and Heterogeneous Domain Adaptation （HDA）， the accuracy of the proposed method was improved by 7.8% to 42.8%， and the F1 score reached 85.0% to 99.0%， while the traditional machine learning and HDA had high accuracy but low recall due to the imbalance of positive and negative samples. Experimental results show that TCA combined with SVM can effectively improve the accuracy and F1 score of liver transplantation complication prediction.